| Show # | Air Date | Tape Date | Season | Type | Contestants | Comments |
|---|---|---|---|---|---|---|
| 8545 | 2021-12-31 | 2021-10-12 | 38 | Regular | Arjun Sivakumar, Dan Patton, Amy Schneider | Amy Schneider game 23. |
| 8544 | 2021-12-30 | 2021-10-12 | 38 | Regular | Sarah Wrase, Nate Levy, Amy Schneider | Amy Schneider game 22. |
| 8543 | 2021-12-29 | 2021-10-12 | 38 | Regular | Joanna Wu, Ben Walthall, Amy Schneider | Amy Schneider game 21. |
| 8542 | 2021-12-28 | 2021-10-12 | 38 | Regular | Chas Abdel-Nabi, Josette Curtis, Amy Schneider | Amy Schneider game 20. |
| 8541 | 2021-12-27 | 2021-10-12 | 38 | Regular | Donna Lettow, Ashley Castle, Amy Schneider | Amy Schneider game 19. |
| 8540 | 2021-12-24 | 2021-10-11 | 38 | Regular | Chris O'Malley, David Carpman, Amy Schneider | Amy Schneider game 18. |
| 8539 | 2021-12-23 | 2021-10-11 | 38 | Regular | Andrew Tyler, Kelly Hartman, Amy Schneider | Amy Schneider game 17. |
| 8538 | 2021-12-22 | 2021-10-11 | 38 | Regular | Krystina Alfano, Jamal Rogers, Amy Schneider | Amy Schneider game 16. |
| 8537 | 2021-12-21 | 2021-10-11 | 38 | Regular | Jason Snyder, Kaitlyn Pesterfield, Amy Schneider | Amy Schneider game 15. |
| 8536 | 2021-12-20 | 2021-10-11 | 38 | Regular | Do Park, Erin Creed, Amy Schneider | Amy Schneider game 14.Ken Jennings hosts. |
| 8525 | 2021-12-03 | 2021-10-05 | 38 | Regular | Andrew Rafner, Brooke Sachs, Amy Schneider | Amy Schneider game 13. |
| 8524 | 2021-12-02 | 2021-10-05 | 38 | Regular | Jessica Morgan, Sinnott Martin, Amy Schneider | Amy Schneider game 12. |
| 8523 | 2021-12-01 | 2021-10-05 | 38 | Regular | David Miller, Jaimie Carlson, Amy Schneider | Amy Schneider game 11. |
| 8522 | 2021-11-30 | 2021-10-05 | 38 | Regular | Krys Fischer, Pam Schoenberg, Amy Schneider | Amy Schneider game 10.This episode was submitted for consideration for the Daytime Emmy Award for Outstanding Game Show, and won. |
| 8521 | 2021-11-29 | 2021-10-05 | 38 | Regular | Andrea Asuaje, Nishanth Iyengar, Amy Schneider | Amy Schneider game 9. |
| 8520 | 2021-11-26 | 2021-10-04 | 38 | Regular | Greta Perel, Chris Rayis, Amy Schneider | Amy Schneider game 8. |
| 8519 | 2021-11-25 | 2021-10-04 | 38 | Regular | Ged Trias, Nancy Edelman, Amy Schneider | Amy Schneider game 7. |
| 8518 | 2021-11-24 | 2021-10-04 | 38 | Regular | Dan Brady, Madeline Hornsey, Amy Schneider | Amy Schneider game 6. |
| 8517 | 2021-11-23 | 2021-10-04 | 38 | Regular | Matt King, Genesis Whitlock, Amy Schneider | Amy Schneider game 5. |
| 8516 | 2021-11-22 | 2021-10-04 | 38 | Regular | Mack Hayden, Heidi Stumb, Amy Schneider | Amy Schneider game 4. |
| 8515 | 2021-11-19 | 2021-09-28 | 38 | Regular | Chi-Nhan Vo, Gordon Spates, Amy Schneider | Amy Schneider game 3. |
| 8514 | 2021-11-18 | 2021-09-28 | 38 | Regular | Taylor Mills, Bonnie Lapwood, Amy Schneider | Amy Schneider game 2. |
| 8513 | 2021-11-17 | 2021-09-28 | 38 | Regular | Amy Schneider, Max McDonald, Andrew He | Andrew He game 6.Amy Schneider game 1. |
| 8512 | 2021-11-16 | 2021-09-28 | 38 | Regular | Rebecca Clark, Michael Guarnieri, Andrew He | Andrew He game 5. |
| 8511 | 2021-11-15 | 2021-09-28 | 38 | Regular | Jeff Meyers, Molly Karol, Andrew He | Andrew He game 4. |
| 8510 | 2021-11-12 | 2021-09-27 | 38 | Regular | Brennan Harkin, Dorothy Lam Frey, Andrew He | Andrew He game 3. |
| 8509 | 2021-11-11 | 2021-09-27 | 38 | Regular | Tucker Shope, Willa Perlmutter, Andrew He | Andrew He game 2. |
| 8508 | 2021-11-10 | 2021-09-27 | 38 | Regular | Andrew He, Mary Kamela, Dane Reighard | Andrew He game 1. |
| 8507 | 2021-11-09 | 2021-09-27 | 38 | Regular | Hillary Sebeny, Greg Zona, Dane Reighard | |
| 8506 | 2021-11-08 | 2021-09-27 | 38 | Regular | Elena Passarello, Dane Reighard, Kate Kohn | First game with Ken Jennings introduced as hosting.Episode ended with a title card reading, "Alex Trebek / July 22, 1940 – November 8, 2020 / You are missed every day." |
| 8505 | 2021-11-05 | 2021-09-24 | 38 | Regular | Jeff Smith, Kate Kohn, Sri Kompella | Last regular-play game of 2021 hosted by Mayim Bialik. |
| 8504 | 2021-11-04 | 2021-09-24 | 38 | Regular | Sri Kompella, Cindy Zhang, Tony Freitas | |
| 8503 | 2021-11-03 | 2021-09-24 | 38 | Regular | Julian Huerta, Tony Freitas, Tyler Rhode | Tyler Rhode game 6. |
| 8502 | 2021-11-02 | 2021-09-24 | 38 | Regular | Chuck McKeever, Abby Haddican, Tyler Rhode | Tyler Rhode game 5. |
| 8501 | 2021-11-01 | 2021-09-24 | 38 | Regular | Carrie Bruner, Mike Norris, Tyler Rhode | Tyler Rhode game 4. |
| 8500 | 2021-10-29 | 2021-09-23 | 38 | Regular | Wren Romero, Emily Robinson, Tyler Rhode | Tyler Rhode game 3. |
| 8499 | 2021-10-28 | 2021-09-23 | 38 | Regular | Judi Dimund, Peter Stein, Tyler Rhode | Tyler Rhode game 2. |
| 8498 | 2021-10-27 | 2021-09-23 | 38 | Regular | Jennifer Mosher, Tyler Rhode, Nancy Donehower | Tyler Rhode game 1. |
| 8497 | 2021-10-26 | 2021-09-23 | 38 | Regular | Mandela Namaste, Nancy Donehower, Jonathan Fisher | Jonathan Fisher game 12. |
| 8496 | 2021-10-25 | 2021-09-23 | 38 | Regular | Hilary Bouxsein, Stephen Son, Jonathan Fisher | Jonathan Fisher game 11. |
| 8495 | 2021-10-22 | 2021-09-10 | 38 | Regular | Rudy Fernández-Dieppa, Lea Zaric, Jonathan Fisher | Jonathan Fisher game 10. |
| 8494 | 2021-10-21 | 2021-09-10 | 38 | Regular | Holly Van Leuven, Erin Coningsby, Jonathan Fisher | Jonathan Fisher game 9. |
| 8493 | 2021-10-20 | 2021-09-10 | 38 | Regular | Anjolie Chidambaram, Jack Hodges, Jonathan Fisher | Jonathan Fisher game 8. |
| 8492 | 2021-10-19 | 2021-09-10 | 38 | Regular | Olivia Cammisa-Frost, Katy Buckner, Jonathan Fisher | Jonathan Fisher game 7. |
| 8491 | 2021-10-18 | 2021-09-10 | 38 | Regular | Anna Wright, Adam George, Jonathan Fisher | Jonathan Fisher game 6. |
| 8490 | 2021-10-15 | 2021-09-09 | 38 | Regular | Connie Smith, Nima Aghili, Jonathan Fisher | Jonathan Fisher game 5. |
| 8489 | 2021-10-14 | 2021-09-09 | 38 | Regular | Ray Kimball, Aline Dolinh, Jonathan Fisher | Jonathan Fisher game 4. |
| 8488 | 2021-10-13 | 2021-09-09 | 38 | Regular | Mary Garvey, Bilal Ali, Jonathan Fisher | Jonathan Fisher game 3. |
| 8487 | 2021-10-12 | 2021-09-09 | 38 | Regular | Robinson-Gissette Cruz, Brittany Iburg, Jonathan Fisher | Jonathan Fisher game 2. |
| 8486 | 2021-10-11 | 2021-09-09 | 38 | Regular | Jonathan Fisher, Jessica Stephens, Matt Amodio | Matt Amodio game 39.Jonathan Fisher game 1.Jessica Stephens game 1.First game with Michael Davies as executive producer. |